淞 Posted in Sydney Brenner says for past 50 years life science has changed into Low Input, High Throughput, No Output science.
This is brilliantly sharp !!!
As I can tell, most people thought systems biology is simply dealing with large mount of data. Well, I guess they are likely going into a wrong way.
I strongly recommend this interview with Sydney Brenner in Nature Review Molecular Cell Biology and another one I have read from somewhere that about focusing on the information flow in biological system (while I can not remember where did I read it.) {Remark: I found the 2nd article later, it is Life, Logic and Information written by Paul Nurse on Nature, 2008}
There are some interesting point of view about biology and research in life science. It is worthy of reading and thinking for biological students.
The biggest problem here is that, as Tim Hunt said in Nature video on 16/09/2010, it is hard to let people believe that the whole static picture of which one interacting with which another one, prediction of the possibilities that interaction might happen which probably is not true. And for real, mechanistic and causative questions are more rarely asked nowadays.
In contrary, the mechanism-based approach should be superimposed and more accentuated rather than put more and more funds and human resource into data-driven statistical inference, as there are so much fuzzy noise and, what’s more, the information lost in every step of investigation. Lots of research in this field is kind of like "garbage in, garbage out". The results could possibly never be read by other people forever since published.
Well, no offence to statistics, I just don’t believe it is the way out. It is for sure that time will tell the truth.
PS：最后我要诅咒一下校内的状态更新的140字限制。。。本来想要发一条状态好了，结果不管怎么改都说超过140字，人人网可以去死了 =。=
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